Welcome to the fascinating world of cell wall synthesis inhibitors, where we will venture into the realm of one of the most clinically used antibiotics, the penicillins. They are broad-spectrum antibiotics, meaning they attack more than one species of bacteria. We’ll explore each drug, its mechanism of action, its side effects, and so on.
Penicillin structure consists of a fused β-lactam ring (so it’s also called a β-lactam antibiotic) and a thiazolidine ring (Figure 1). An amide and a carboxylic acid group are also present. The variation is mostly limited to the side chain (R) group of the amide, but prodrugs have been developed by modifying the carboxylic acid.
- Describe penicillins and list common examples.
- Describe the pharmacokinetics and mechanism of action of penicillins.
- Describe the major mechanisms of resistance of bacteria against penicillins and how they developed.
- Differentiate the types of penicillins.
- Describe the major clinical uses of penicillins, including major types of susceptible bacteria.
- Describe the adverse reactions of penicillins.
You can also check out the original brick from our Microbiology collection, which is available for free.
You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks. After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.
If you enjoyed this episode, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world.
Follow USMLE-Rx at:
Learn how you can access over 150 of our bricks for FREE: https://www.usmle-rx.com/free-bricks/